INTRODUCTION: Sleeve gastrectomy is associated with an increased incidence of gastroesophageal reflux disease (GERD). In contrast, the impact of endoscopic gastric remodeling (EGR) on GERD symptoms remains unclear.

METHODS: This prospective study included patients who underwent EGR and completed validated GERD-related patient-reported outcome questionnaires at baseline and 12 months post-procedure.

RESULTS: Fifty patients were included. At 12 months post-EGR, both GERD-Q and Reflux Symptom Index scores significantly improved. Proton pump inhibitor (PPI) use decreased from 38% at baseline to 20% at 12 months (p=0.047). The presence of a hiatal hernia at baseline was associated with greater symptom improvement.

DISCUSSION: EGR improves both typical and atypical GERD symptoms and reduces PPI dependence. It may represent a preferable treatment option for patients with obesity and concomitant GERD.